Isaac Guerendo

NFL player. Position: RB. Team: SF.

Quick Facts

Position: Running Back
Team: SF (San Francisco 49ers)
Age: 25
Bye week (2026): 10
FantasyPros PPR rank (2026): TBD
Draft: 2024 (4th round)

2026 Outlook

Guerendo showed promise as a 2024 rookie (430 rushing yards on 84 carries, 4 TDs) but regressed dramatically in Year 2, seeing zero offensive snaps after the 49ers acquired Brian Robinson. He's competing for depth snaps behind Christian McCaffrey but suffered a torn pectoral muscle lifting weights in late May, sidelining him until late in training camp. The injury derails any momentum he might've gained in a rebuild year. (per Nick Bosa says he is on track for training camp and Week 1 with the 49ers)

Role / Depth Chart

Third-team RB behind Christian McCaffrey and Brian Robinson.

Injury Status

Torn pectoral muscle (sustained May 2026, lifting weights). Expected to be sidelined until late training camp. (per Nick Bosa says he is on track for training camp and Week 1 with the 49ers)

Recent News

2026-05-08 — 49ers’ offense will glow when stars Brock Purdy, George Kittle return (49ers’ offense will glow when stars Brock Purdy, George Kittle return)
2026-04-30 — Rating the 2026 NFL Rookie Running Backs: Post-NFL Draft Rookie Super Model Ratings (Rating the 2026 NFL Rookie Running Backs: Post-NFL Draft Rookie Super Model Ratings)
2026-05-05 — RB Isaac Guerendo In Uphill Battle To Make 49ers’ Roster; Latest On Team’s LG Situation (RB Isaac Guerendo In Uphill Battle To Make 49ers’ Roster; Latest On Team’s LG Situation)
2026-05-27 — 6 position battles worth keeping an eye on during 49ers OTAs (6 position battles worth keeping an eye on during 49ers OTAs)
2026-04-15 — Ryan Heath's 2026 Rookie RB Rankings (Ryan Heath's 2026 Rookie RB Rankings)
2026-05-04 — Dynasty Rookie Draft Primer: RB Rankings & Tiers (Fantasy Football) (Dynasty Rookie Draft Primer: RB Rankings & Tiers (Fantasy Football))
2026-05-27 — Latest on Josh Jacobs and Fantasy Football Potential for Chris Brooks, MarShawn Lloyd... (Latest on Josh Jacobs and Fantasy Football Potential for Chris Brooks, MarShawn Lloyd...)
2026-04-26 — 2026 NFL draft grades for 32 teams: Winners, losers, steals (2026 NFL draft grades for 32 teams: Winners, losers, steals)
2026-05-12 — Brain Trust: 2026 Favorite Rookie Landing Spots (Brain Trust: 2026 Favorite Rookie Landing Spots)
2026-05-28 — Nick Bosa says he is on track for training camp and Week 1 with the 49ers (Nick Bosa says he is on track for training camp and Week 1 with the 49ers)

Open Questions

Will Guerendo's pectoral injury cost him chances to fight his way back onto the field in 2026, or can he make a preseason splash?