Yes, it's very likely. The Washington Commanders have been actively exploring veteran receiver additions to help Jayden Daniels, and the wiki points to two strong candidates (from the Washington Commanders page):
Brandon Aiyuk — Aiyuk is the most intriguing option. He played with Daniels at Arizona State, and GM Adam Peters came from the 49ers front office where Aiyuk was drafted. The 49ers have voided his guarantees and signed Mike Evans, signaling they're moving on. Washington has post-June 1 cap flexibility to make a move. The biggest question: Aiyuk missed all of 2025 with a torn ACL and hasn't played since 2024.
Stefon Diggs — Prediction markets have Washington as the top landing spot for the 32-year-old free agent (33 cents per share on Kalshi). Diggs just put up 1,013 yards with the Patriots in 2025, and his route precision is a great fit for OC David Blough's under-center scheme — arguably better than Deebo Samuel was last year.
On Underdog Fantasy, Josh & Hayden discussed the Aiyuk situation, noting that "the longer they [the 49ers] wait, the more likely the Commanders are going to say, 'You know what? I'm going to send you a seventh-round pick'" — suggesting a trade could happen at a discount [].
Bottom line: The Commanders lost ~150 targets this offseason (Deebo, etc.) and the WR2 job behind Terry McLaurin is wide open. They've got the cap flexibility, the GM connections, and the need. Aiyuk feels like the most likely outcome given the personal connections, but Diggs is a real fallback option.